Sepsis-Associated Acute Kidney Injury
Conditions
Interventions
Sepsis group:None
Sepsis-Associated Acute Kidney Injury (SA-AKI) group:None
Other types of acute kidney injury group:None
Sponsors
The First Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age> = 18 years; 2. Sepsis patients who meet the criteria of sepsis-3; 3. Patients with sepsis are diagnosed with SA-AKI when serum creatinine increases by 0.3 mg/dl (>26.5 umol/L) over 48 hours, or increases to more than 1.5 times the baseline value, or urine output decreases to no more than 0.5 mL/kg/hour for at least 6 hours, according to the Kidney Disease Improvement Overall Outcome (KDIGO) guidelines.
Exclusion criteria
Exclusion criteria: 1. Discharged or died within 48 hours of admission; 2. Chronic kidney disease (CKD) or other known kidney disease; 3. Receiving renal replacement therapy (such as hemodialysis, peritoneal dialysis) before admission; 4. Kidney transplantation or nephrectomy; 5. Serious diseases, such as malignant tumors, autoimmune diseases, acquired immunodeficiency diseases; 6. Pregnant or lactating women; 7. Insufficient clinical information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 3-Methylhistidine;Inosine;Creatine;3- hydroxybutyric acid;Arginine;Neutrophil Gelatinase-Associated Lipocalin;Kidney Injury Molecule-1;AKI diagnosis time;Recovery time of renal function;The duration of CRRT treatment;7-day mortality rate;28-day mortality rate;Hospitalization mortality;Sequential Organ Failure Assessment Score;Acute Physiology and Chronic Health Evaluation II Score;Duration of Mechanical Ventilation;Creatinine;Blood Urea Nitrogen;Urinary Output;Fatty acid-binding protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Length of stay in ICU;Total Hospitalization Duration;Blood Lactate;Interleukin-6;Procalcitonin;C-Reactive Protein;D-dimer;Albumin;Site of Infection; | — |
Countries
China
Contacts
Public ContactWang Changsong
The First Affiliated Hospital of Harbin Medical University
Outcome results
None listed