FindTrial
Sign In

The Correlative Study between Summary SVD score based on multimodal Imaging and Cognitive Impairment in Patients with Parkinson's Disease

The Correlative Study between Summary SVD score based on multimodal Imaging and Cognitive Impairment in Patients with Parkinson's Disease

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104579
Enrollment
Unknown
Registered
2025-06-19
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson disease

Interventions

Trial group:Non

Sponsors

Shanxi Bethune Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Meeting the Chinese Diagnostic Criteria for Parkinson’s Disease (2016 Edition), with PD diagnosis confirmed by clinical history and Unified Parkinson’s Disease Rating Scale (UPDRS) assessment. 2. Disease Severity.Hoehn & Yahr (HY) stages 1–3. 3. Neuroimaging Requirements Complete cranial MRI sequences, including T1-weighted, T2-weighted, DWI, FLAIR, and SWI. 4. Transcranial Doppler (TCD) Feasibility:Adequate bilateral temporal bone windows for supine-standing TCD and functional TCD examinations. 5. Compliance & Ethics ;Ability to undergo cognitive assessments and provide written informed consent.

Exclusion criteria

Exclusion criteria: 1. Comorbid Neurological/Motor Disorders:Concurrent gait-affecting conditions (e.g., spinal cord/joint injuries, muscle spasms, stroke, peripheral neuropathy, myopathies, hydrocephalus, or cognitive impairment). Malignancies, unstable/severe systemic diseases. 2. Atypical Parkinsonian Syndromes Secondary parkinsonism, parkinsonism-plus syndromes (e.g., MSA, PSP), or familial Parkinson’s disease. 3. Organ Failure & Neurological/ Psychiatric History;History of organ failure (cardiac, pulmonary, hepatic, renal), brain trauma, intracranial tumors, encephalitis, intracranial hypertension, bleeding diathesis, or epilepsy.Neuropsychiatric disorders (e.g., schizophrenia, severe anxiety/depression) or uncooperative behavior.Cognitive impairment due to stroke, brain tumors, hydrocephalus, etc.Surgical/Device Contraindications 4. Prior deep brain stimulation (DBS), ablation surgery, or implanted devices (pacemakers, neurostimulators, metal implants). 5. Pharmacological & Functional Limitations. Recent use of autonomic nervous system-affecting medications. 6. Severe visual/hearing impairment or dementia precluding cognitive assessments. 7. Severe comorbidities with <1-year survival prognosis.

Design outcomes

Primary

MeasureTime frame
Cognitive decline;Summary SVD score;—

Countries

China

Contacts

Public ContactKaili Zhang

Shanxi Bethune Hospital

zhangkaili-2009@163.com+86 187 3489 0284

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026