The Effects of Dural Puncture Epidural Block Versus Combined Spinal-Epidural Anesthesia on Post-Anesthetic Hypotension in Morbidly Obese Parturients Undergoing Cesarean Delivery

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2500104551

Enrollment

Unknown

Registered

2025-06-18

Start date

2025-06-30

Completion date

Unknown

Last updated

2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia-related hypotension in morbidly obese parturients undergoing cesarean delivery

Interventions

CSEA group: Parturients receiving Combined Spinal-Epidural Anesthesia (CSEA):The parturients in this group undergo cesarean section under combined spinal-epidural anesthesia (CSEA).

DPE+EA group: Parturients receiving Dural Puncture Epidural (DPE) combined with Epidural Anesthesia (EA).:The parturients undergo cesarean section under Dural Puncture Epidural (DPE) combined with Epi

Eligibility

Sex/Gender

Female

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: ASA Class II-III, meeting the anesthesia risk assessment standards; Gestational age >= 37 weeks, singleton pregnancy; Age >= 18 years; Obesity (BMI >= 40 kg/m^2); Scheduled cesarean section under neuraxial anesthesia; Parturients voluntarily participating in the study and signing a written informed consent.

Exclusion criteria

Exclusion criteria: Pregnant women with diabetes, hypertension, preeclampsia, eclampsia, cardiovascular diseases, placenta previa, or placental abruption; Contraindications to neuraxial anesthesia, such as allergy to anesthetic drugs, coagulopathy, anticoagulant therapy, severe hypovolemia, or hemodynamic instability; History of psychiatric disorders or other significant systemic organ diseases; Parturients who have not signed the written informed consent.

Design outcomes

Primary

Measure	Time frame
Incidence of post-anesthesia hypotension;	—

Secondary

Measure	Time frame
Time to achieve sensory block level at T6;Incidence of intraoperative nausea and vomiting;Dosage of vasoactive drugs;Maternal satisfaction;Surgeon satisfaction;Maternal pain VAS score at skin incision;Intraoperative additional analgesic dosage;Neonatal Apgar score ;Neonatal weight;	—

Countries

China

Contacts

Public ContactHan Dan

Jilin Hospital, Women’s Hospital, Zhejiang University School of Medicine

45589404@qq.com+86 1739007650

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026