Postoperative delirium
Conditions
Interventions
Esketamine group:Esketamine 0.25mg/kg was administered during induction intubation and esketamine 0.1mg/kg/h was pumped continuously during anesthesia maintenance until the end of surgery.
Dexmedetomidine group:During induction of anesthesia, 0.5ug/kg/h dexmedetomidine was administered for 10 minutes, then 0.2-0.7ug/kg/h dexmedetomidine was pumped continuously during maintenance of anes
Normal saline group:Equal dose of normal saline was given during induction intubation, and continuous pumping of normal saline was given during anesthesia maintenance until the end of the operation.
Sponsors
The second affiliated hospital of guangzhou medical university, Guangzhou, China.
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age 65-80 years old; (2) Orthopedic joint replacement surgery under general anesthesia should be performed at an appropriate time. (3) Preoperative Amstedin scale >= 12 points; (4) American Society of Anesthesiologists (ASA) Grade I to III
Exclusion criteria
Exclusion criteria: (1) illiteracy; (2) deafness (3) Patients at serious risk of elevated blood pressure or intracranial pressure (e.g Arterial dissection, intracranial aneurysm, etc.) (4) Poorly controlled or untreated hyperemia Hypertensive patients (high blood pressure in motor pulse, excessive resting systolic/diastolic pressure) 180/100mmHg); ; (5) Abnormal liver and kidney function, abnormal liver function is defined as glutamic acid transamination Enzyme (AST) and/or alanine aminotransferase (ALT) levels exceed 1.5 times the upper limit of normal (ULN), and renal dysfunction is defined as serum creatinine (Cr) >= 1.5 times ULN. ; (6) Body mass index >30kg/m^2; (7) Patients with mental illness or language communication barriers Sedative drugs, antidepressants and other drugs commonly used to affect drug metabolism; (8) untreated or Patients with undertreated hyperthyroidism (hyperthyroidism); (9) Acute closed Angle blue A light-eyed patient; (10) Complicated with ischemic heart disease and congestive heart failure Patient; (11) Diseased sinus syndrome, second or third degree heart block, or clinically significant Patients with sinus bradycardia; (12) The activity of esketamine and dexmedetomidine Patients allergic to either or all excipients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium;perioperative haemodynamics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative anxiety;Postoperative pain;Postoperative sleep quality; | — |
Countries
China
Contacts
Public Contactlingzhi wang
The second affiliated hospital of guangzhou medical university, Guangzhou, China.
Outcome results
None listed