Anesthesia and neurocognitive function
Conditions
Interventions
Experimental Group:Esketamine was pumped at 0.2mg/kg/h from 10min before induction until 10min before the end of surgery
Control group:Normal saline was pumped at 0.2mg/kg/h from 10min before induction until 10min before the end of surgery
Sponsors
Affiliated Hospital of Qinghai University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.American Society of anesthesiologists (ASA) grade ?~?; 2.age >=60 years old; 3. Body Mass Index (BMI) : 18-30m^2; 4.The type of surgery was laparoscopic-assisted radical resection of gastrointestinal tumors (gastric cancer, colorectal cancer); 5.The operation time is limited to 3 to 5 hours; 6.native altitude>=2500m; 7.barrier-free Chinese understanding and writing.
Exclusion criteria
Exclusion criteria: 1.long-term use of opioids for chronic pain or cancer pain; 2.History of alcohol abuse; 3. history of hypertension, coronary heart disease, diabetes mellitus, hyperthyroidism, occlusive vasculitis, severe hepatorenal disease or anemia; 4.allergy to subject-related anesthetic drugs; 5.long-term use of drugs affecting the function of the neuropsychiatric system (such as hypnotics, anxiolytics, antidepressants, etc.); 6.preoperative history of neurological or psychiatric diseases (such as cerebral thrombosis, cerebral infarction, intracranial hypertension, intracranial space occupying lesions, or senile dementia, etc.) or traumatic brain injury; 7.auditory and visual impairment; 8.other surgery in the past month; 9.Preoperative MMSE score of illiterate < 17 points, primary school < 20 points, junior high school or above < 24 points; 10.Inability to understand or communicate with patients on the scale.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure;Heart rate;oxygen saturation of blood;Dosage of Propofol;Dosage of remifentanil ;Dosage of norepinephrine;Time for resuming spontaneous breathing;Time for awakening;Visual analogue scale;Delirium assessment;Cognitive Function Assessment;Interleukin-10;C-reactive protein;S100 ß protein; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of choking and coughing upon extubation;The first time of gastrointestinal tract ventilation after surgery;The first self-administration time of the analgesic pump within 24 hours after surgery;The frequency of patient-controlled analgesia with the analgesic pump within 24 hours after surgery;The satisfaction score of analgesia ;Time of first use dezocine in 24 hours after surgery;Dosage of dezocine in 24 hours after surgery;Occurrence of nausea and vomiting within 24 hours after surgery ; | — |
Countries
China
Contacts
Public ContactTang jing
Affiliated Hospital of Qinghai University
Outcome results
None listed