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Application of low load blood flow restriction resistance training in patients with chronic obstructive pulmonary disease complicated with muscle atrophy

Application of low load blood flow restriction resistance training in patients with chronic obstructive pulmonary disease complicated with muscle atrophy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104537
Enrollment
Unknown
Registered
2025-06-18
Start date
2025-06-20
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic obstructive pulmonary disease with muscular dystrophy

Interventions

Control group1:Low-load resistance training.Patients will undergo resistance training for 30 minutes per session using TheraBand elastic bands as intervention, administered twice a day for one week.
Control group2:High-load resistance training. The patient will receive 30 minutes of resistance training each time and use the TheraBand elastic band for intervention, twice a day for 30 minutes each
Intervention group:Resistance training with low-load blood flow restriction. The patient will receive 30 minutes of low-load blood flow restriction resistance training intervention twice a day, using

Sponsors

Affiliated Hospital of Southwest Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Diagnosed with COPD complicated with sarcopenia; 2. Age>=18 years; 3. The skin of the thighs of both lower limbs is intact and undamaged. 4. Be conscious and able to cooperate with the operation 5. Diagnostic criteria: The diagnosis of COPD meets the 2024 diagnostic criteria of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) of COPD; Sarcopenia is diagnosed using the Asian Working Group for Sarcopenia (AWGS) criteria.

Exclusion criteria

Exclusion criteria: 1. History of deep vein thrombosis, coagulation disorders; 2. Patients with lower limb fractures, history of fractures or edema, etc., who are not suitable for mobility; 3. Abnormal coagulation function; 4. History of lower limb revascularization; 5. Dialysis access or deep venous catheterization in the veins of the lower limbs; 6. Cardiovascular disease: uncontrolled hypertension (systolic blood pressure > 160 or diastolic blood pressure > 100mmHg), history of stroke, acute myocardial infarction, angina pectoris, and uncontrolled ventricular tachycardia. 7. People who have regularly taken the following medications in the past 3 months: antiplatelet drugs (e.g., aspirin, cilostazol, agrenol, cilostazol, ticlopidine, eptifibatide, and tirofiban), analgesics, and anticoagulant medications.

Design outcomes

Primary

MeasureTime frame
Quadriceps strength;Quadriceps thickness;Cross-sectional area of rectus femoris;

Secondary

MeasureTime frame
Hand grip strength;CAT score sheet score;6-minute walk test;MMRC scale;Blood pressure;Blood oxygen saturation;Heart rate;

Countries

China

Contacts

Public ContactZheng Ling

The Affiliated Hospital of Southwest Medical University

498073954@qq.com+86 182 0834 1409

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026