cardiac valve disease
Conditions
Interventions
hemoperfusion group:The HA380 hemoperfusion device was utilized during cardiopulmonary bypass (CPB)
control group:Use of standard cardiopulmonary bypass techniques
Sponsors
The First Affiliated hospital of Xinjiang Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adult patients (aged >=18 years) scheduled to undergo cardiac valve replacement surgery under general anesthesia with cardiiopulmonary bypass were included in this study.
Exclusion criteria
Exclusion criteria: Patients meeting any of the following criteria would be excluded: (1) refusal to provide written informed consent; (2) preoperative confirmed cognitive dysfunction, alzheimer's disease, epilepsy, and other mental disorders.; (3) inability to communicate due to visual, hearing, speech, or other impairments; (4) history of brain injury or neurosurgery; (5) left ventricular ejection fraction =2 degrees of atrioventricular block; (7) severe hepatic failure (Child-Pugh class C); (8) severe renal failure (requiring renal replacement therapy); and (9) patients with allergies to experimental medications and to haemoperfusion devices, filters, and anticoagulants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Postoperative Delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factor levels(IL-1ß,,IL-6,,TNF- a,,CPR);Brain injury marker levels( S100ß,NSE);Postoperative cognitive function;Duration of mechanical ventilation;Length of ICU hospital stay;Total Hospital Stay;Postoperative complications;30-day postoperative cognitive function; | — |
Countries
China
Contacts
Public ContactHu Zhenfei
The First Affiliated hospital of Xinjiang Medical University
Outcome results
None listed