Sepsis
Conditions
Interventions
Sepsis/ARDS Group:None
Non-Sepsis/ARDS Group:None
Healthy Control Group:None
Sponsors
The First Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Sepsis/ARDS group (1) Confirmed diagnosis of sepsis (in line with Sepsis 3.0 criteria)/ARDS (in line with the 2023 global definition of ARDS) within 48 hours of ICU admission; (2) Signed informed consent. 2. Non-sepsis/ARDS group; (1) Patients with severe non-sepsis/ARDS who have at least one or more organ dysfunction. (2) Signed informed consent. 3. Healthy control group (1) Signed informed consent; (2) There was no obvious abnormality in the results of physical examination.
Exclusion criteria
Exclusion criteria: 1. Sepsis/ARDS group (1) Survival time and ICU stay time less than 48 hours; (2) Age< 18 years old; (3) people with diseases that can cause neutrophil changes (such as autoimmune diseases, hematologic diseases, radiotherapy and chemotherapy); (4) People with a history of organ transplantation (patients who need to take immunosuppressants for a long time); (5) pregnant women; (6) Those who are unwilling to sign the consent form 2. Non-sepsis/ARDS group (1) Survival time and ICU stay time less than 48 hours; (2) Age< 18 years old; (3) people with diseases that can cause neutrophil changes (such as infections, autoimmune diseases, hematologic diseases, radiotherapy and chemotherapy); (4) People with a history of organ transplantation (patients who need to take immunosuppressants for a long time); (5) pregnant women; (6) Those who are unwilling to sign the consent form. 3. Healthy control group (1) Age< 18 years old; (2) people with diseases that can cause neutrophil changes (such as infections, autoimmune diseases, hematologic diseases); (3) People with a history of organ transplantation (patients who need to take immunosuppressants for a long time); (4) Patients with chronic diseases such as hypertension, diabetes, coronary heart disease, etc., including patients with tumors; (5) Those who are unwilling to sign the consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neutrophil Functional Indicators;Acute Physiology and Chronic Health Evaluation II, APACHE?;Neutrophil Mechanical Indicators;Sequential Organ Failure Assessment, SOFA;Neutrophil Morphological Indicators; | — |
Countries
China
Contacts
Public ContactSang Ling
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed