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Study on the effect of caloric restriction on glucose metabolism by down-regulating LCN2 activation of PI3K-NTRK 2 pathway in the treatment of metabolic syndrome

Study on the effect of caloric restriction on glucose metabolism by down-regulating LCN2 activation of PI3K-NTRK 2 pathway in the treatment of metabolic syndrome

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104519
Enrollment
Unknown
Registered
2025-06-18
Start date
2025-06-20
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Metabolic syndrome

Interventions

Experimental group:Caloric restriction

Sponsors

Xiamen Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: These include a diagnosis of MetS and age 18 to 65 years, glycosylated hemoglobin = 90 cm for men and > = 80 cm for women, plus any two of the following 4 factors: 1. Elevated triglyceride (TG) level >=1.7 mmol/L, or have received special treatment for this lipid abnormality; 2. Decreased levels of high-density lipoprotein cholesterol (HDL-C): 1.03 mmol/L =130mmHg or diastolic blood pressure >=85mmHg, or has been previously diagnosed with hypertension for treatment; 4. Elevated fasting blood glucose: fasting blood glucose (FBG) >=5.6mmol/L, or has been diagnosed with type 2 diabetes.

Exclusion criteria

Exclusion criteria: These include pregnancy, lactation, severe heart disease, severe liver disease (except fatty liver), malnutrition, heavy smoking, substance abuse, cancer, or any serious systemic illness.

Design outcomes

Primary

MeasureTime frame
Blood glucose;Fasting Insulin;Total Cholesterol;Triacylglycerol;High density lipoprotein cholesterol;Low-Density Lipoprotein;Serum metabolites;Lipocalin-2,LCN2;

Countries

China

Contacts

Public ContactYi Zhou

Xiamen Hospital of Traditional Chinese Medicine

yizhou_79@163.com+86 137 2089 9619

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026