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Multidimensional Risk Profiling and Dynamic Early-Warning Model Construction for Acute Myocardial Infarction in High-Risk Populations of Western China: A Multicenter Prospective Cohort Study

Multidimensional Risk Profiling and Dynamic Early-Warning Model Construction for Acute Myocardial Infarction in High-Risk Populations of Western China: A Multicenter Prospective Cohort Study

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104518
Enrollment
Unknown
Registered
2025-06-18
Start date
2025-08-01
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute myocardial infarction

Interventions

According to ethnicity, they are divided into four groups: Han, Hui, Tibetan and Kazakh.:None

Sponsors

Gansu Provincial Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 79 Years

Inclusion criteria

Inclusion criteria: 1. Adults aged 30–79 years; 2. Estimated 10-year ASCVD risk >=20% based on China-PAR; 3. Permanent residency in the study region (>=6 months/year); 4. Ability to provide written informed consent; 5. Willingness to participate in repeated data and biospecimen collection.

Exclusion criteria

Exclusion criteria: 1. History of acute myocardial infarction or coronary revascularization; 2. Terminal illness with life expectancy <1 year; 3. Severe psychiatric or cognitive impairment precluding protocol adherence; 4. Current pregnancy or breastfeeding

Design outcomes

Primary

MeasureTime frame
Lipoprotein-associated phospholipase A2 (Lp-PLA2);Soluble growth - stimulation expressed gene 2 protein (sST2);myeloperoxidase(MPO);Heart-type fatty acid-binding protein (H-FABP);N-terminal pro-brain natriuretic peptide (NT-proBNP);Creatine kinase-MB (CK-MB);High-sensitivity cardiac troponin T(hs-cTnT);

Secondary

MeasureTime frame
High-sensitivity C-reactive protein (hs-CRP);Related indicators of dynamic electrocardiogram monitoring equipment;Indicators related to echocardiogram;area under the curve; AUC;sensitivity;specificity;

Countries

China

Contacts

Public ContactXie Ping

Gansu Provincial Hospital

Pingxie66@163.com+86 139 1976 1522

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Aug 14, 2026