Gastrointestinal Diseases
Conditions
Interventions
Traditional endoscopic screening group:None
Sponsors
National Clinical Research Center for Digestive Diseases/The First Affiliated Hospital of Air Force Medical University
Eligibility
Sex/Gender
All
Age
45 Years to 74 Years
Inclusion criteria
Inclusion criteria: At the time of enrollment, the subjects were aged between 45 and 74 years old and met any of the following criteria: 1. Long-term residence in areas with a high incidence of esophageal cancer or gastric cancer; 2.Hp infection 3. There is a history of esophageal cancer or gastric cancer among first-degree relatives; 4. Previous history of chronic atrophic gastritis, gastric ulcers, gastric polyps, postoperative residual stomach, hypertrophic gastritis, pernicious anemia and other pregastric cancer diseases; Or suffer from chronic esophagitis, Barrett's esophagus, esophageal diverticulum, achalasia of the cardia, reflux esophagitis, benign esophageal stenosis and other esophageal diseases; 5. There are poor dietary habits (such as high-salt, pickled, and hot food) or living habits (such as long-term smoking and heavy drinking).
Exclusion criteria
Exclusion criteria: 1. Undergo upper gastrointestinal endoscopy screening within 1.1 years; 2. The screening benefits are reduced due to severe diseases, such as severe lung diseases, kidney diseases, liver diseases, cardiovascular and cerebrovascular diseases, and blood diseases, etc. 3. Other doctors assessed that the patient was at excessive risk for endoscopic screening (such as unstable hemodynamics) or had no benefit (short expected lifespan); 4.Pregnant or lactating women; 5.Unable to sign the informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastroscopy;RNF180 gene methylation detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| SEPT9 gene methylation detection; | — |
Countries
China
Contacts
Public ContactYongzhan Nie
The First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed