Renal failure
Conditions
Interventions
Control group:Citric acid, displacement solution, and sodium bicarbonate are used independently according to traditional methods.
New Strategy Group:The ratio of waste liquid flow rate to citric acid flow rate is 9-10:1, and no sodium bicarbonate is used.
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Admitted to emergency ICU, age >=18 years old; 2. Application of topical citrate anticoagulation regimen for CRRT treatment; 3. Blood gas analysis before blood purification showed 18mmol/L<=HCO3-<=27mmol/L.
Exclusion criteria
Exclusion criteria: 1. Pregnant patients 2. Presence of severe metabolic acidosis prior to treatment, PH7.45 and (or) HCO3->27 3. There are other etiologies that significantly affect the acid-base balance disorder (severe carbon dioxide retention disease, PCO2>80mmHg 4. Persistent shock that cannot be corrected by applying large doses of hemorrhoidal active drugs, norepinephrine pumping > 1ug/kg·min, dopamine >10ug/kg·min, MAP 10mmol/L 5. Severe fluid loss, such as gastric juice, intestinal juice, and third space fluid loss of more than 2L within 24 hours 6. The duration of CRRT treatment is less than 12 hours 7. Patient or family members are unable to understand the conditions and objectives of this study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of metabolic acid-base imbalance disorder; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete biochemical analysis;Electrolyte;Blood Gas Analysis;Filter lifespan;Sodium bicarbonate usage;The compliance rate of free calcium ions before and after the filter;The incidence of adverse bleeding events;The incidence of citric acid accumulation; | — |
Countries
China
Contacts
Public ContactDingyu Tan
Northern Jiangsu People's Hospital
Outcome results
None listed