Alzheimer’s Disease
Conditions
Interventions
Experimental group:Cervical deep lymphatic/lymph node-venous anastomosis
Sponsors
Baotou Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Meet the core clinical criteria for probable Alzheimer's disease (AD) dementia as per the 2011 NIA-AA revised diagnostic criteria for AD;Can be classified as having moderate or severe Alzheimer's disease: a. Moderate: Progressive cognitive impairment and neuropsychiatric changes; having a widespread impact on daily life, with partial impairment of basic functions, inability to live independently, and often requiring assistance; or a Clinical Dementia Rating (CDR) score of 2.0.b. Severe: Progressive cognitive impairment and neuropsychiatric changes, possibly to the extent that clinical interviews cannot be conducted; having a severe impact on daily life, including impairment of basic activities such as self-care, and being completely dependent on assistance; or a CDR score of 3.0. The subject has good auditory, visual, and language functions, or can complete neuropsychological assessments after correction.The subject and their informant are capable of completing relevant examinations and follow-up visits. The subject or their authorized proxy has signed an informed consent form. 2.Patients who have shown inadequate response to treatment with cholinesterase inhibitors, NMDA receptor antagonists, or other similar medications. 3.Patients without cardiac, pulmonary, hepatic, or renal dysfunction.
Exclusion criteria
Exclusion criteria: 1.Patients with congenital intellectual disability or severe neurological or psychiatric disorders. 2.Patients who have been definitively diagnosed with malignant tumors or failure of vital organs. 3.Patients with severe visual or hearing impairment who are unable to cooperate in neuropsychological assessments. 4.Patients with poor cardiopulmonary function who cannot tolerate anesthesia. 5.Patients with inadequate exposure of the surgical site or whose family members have not signed an informed consent form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive function assessment;Activity of Daily Living Scale;Magnetic Resonance Imaging; | — |
Countries
China
Contacts
Public ContactChangchun Jiang
Baotou Central Hospital
Outcome results
None listed