Epilepsy
Conditions
Interventions
Single group:Different stimulation parameters and targets
Sponsors
Xuanwu Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Aged between 18 and 60 years, regardless of gender; (2) Diagnosed with drug-resistant epilepsy, with focal seizures; drug-resistant epilepsy is defined as failure to achieve sustained seizure freedom after the application of two anti-epileptic drugs (either as monotherapy or in combination); (3) For the stimulation frequency comparison experiment, subjects must have undergone intracranial electrode implantation, with electrode placements including the hippocampus, thalamus, anterior cingulate gyrus, and insula; (4) The patient or their family must fully understand the treatment method, cooperate in completing the clinical trial, and voluntarily sign the informed consent.
Exclusion criteria
Exclusion criteria: (1)Presence of brain tumors or other central neurodegenerative disorders, (2)Significant organic brain alterations (3)Severe cognitive impairment (4)Psychogenic non-epileptic seizures (PNES) (5)Generalized or specific types of hereditary epilepsy (6)Having undergone epilepsy-related surgical interventions within 6 months prior to implantation (7)Women who are lactating or pregnant (8)Participation in other clinical trials within 3 months before screening (9)Pre-existing psychiatric conditions that would preclude required examinations (10)Other severe systemic diseases or clinically significant laboratory abnormalities (e.g., hepatic/renal dysfunction) that may affect follow-up (11)Objective factors preventing completion of follow-up (economic constraints, transportation limitations, etc.) (12)Clinically significant abnormal laboratory findings during screening period (13)Unwillingness to sign informed consent documents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interictal epileptiform discharges and high-frequency oscillations in intracranial EEG recordings before and after each experimental session; | — |
Secondary
| Measure | Time frame |
|---|---|
| Waveform changes in intracranial EEG recordings before and after each experimental session; | — |
Countries
China
Contacts
Public ContactTao Yu
Xuanwu Hospital, Capital Medical University
Outcome results
None listed