Hepatocellular carcinoma
Conditions
Interventions
Direct surgery group:None
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1) Clinically diagnosed or postoperative pathological diagnosis of hepatocellular carcinoma; 2) Resectable primary liver cancer at CNLC stage Ib and IIa; no liver cirrhosis with residual liver volume > 30% or with liver cirrhosis and residual liver volume > 40%; 3) Aged 18-75 years old, good surgical tolerance; Eastern Cooperative Oncology Group performance status score (ECOG PS) 0-1; Child-Pugh A grade, or grade B during the first hospitalization and converted to grade A after treatment; 4) With one or more of the following high-risk recurrence factors: a. Single large HCC (tumor size >= 10 cm); b. Unifocal multifocal disease (2-3 tumors, 1 tumor >= 5 cm); c. AFP >= 400 ng/ml; d. Tumor adjacent to major vascular structures (including the main portal vein, main hepatic vein and inferior vena cava), resulting in a resection margin < 1 cm; 5) The neoadjuvant treatment group underwent at least one interventional treatment and regular anti-angiogenic targeted therapy or immune checkpoint inhibitor therapy before surgical R0 resection.
Exclusion criteria
Exclusion criteria: 1) HCC combined with intrahepatic cholangiocarcinoma; having other malignant tumors except liver cancer within the past 5 years; 2) preoperative tumor rupture and bleeding; 3) having received other anti-tumor treatments before treatment, such as radiofrequency ablation, radiotherapy, systemic treatment, chemotherapy, etc.; 4) the surgery did not achieve R0 resection or ablation treatment was performed on small lesions during the operation; 5) the tumor is operable, but the family refuses the surgery or the data is incomplete.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Overall survival;Objective response rate; | — |
Countries
China
Contacts
Public ContactJianfeng Li
The First Affiliated Hospital of Nanchang University
Outcome results
None listed