elective non-cardiovascular surgery
Conditions
Interventions
Control group (Group C):Sufentanil (0.4µg/kg)
Esketamine Group (S Group):Esketamine(0.5mg/kg)
Sponsors
The Second Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-60 years old; 2.BMI18-28kg/m^2; 3. ASAI.-II. 4. Planned surgery under tracheal intubation and general anesthesia; 5. Subjects voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those who have contraindications to general anesthesia, are allergic to the study drug or have contraindications; 2. Patients with coronary heart disease, heart valve disease, and myocardial segmental systolic disorder; 3. Patients with severe cardiac insufficiency (preoperative LVEF <40% or NYHA grade IV), severe liver and kidney dysfunction; 4. History of neurological or psychiatric diseases or psychotropic medications; 5. Pregnant or lactating women; emergency surgery or cardiovascular surgery; 6. Unable to cooperate or refuse to participate in the participant; 7. Patients who cannot obtain transthoracic echocardiogram images or have poor image quality and cannot be analyzed; 8. Other conditions judged by the investigator to be unsuitable for participating in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular outflow tract velocity time integral( LVOT-VTI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Stroke volume(SV);Occurrence of adverse cardiovascular events;Stroke volume variation (SVV);Cardiac output (CO);Hemodynamic parameters (SBP, DBP, MAP, HR); | — |
Countries
China
Contacts
Public ContactXin Zhao
The Second Hospital of Shandong University
Outcome results
None listed