Sepsis
Conditions
Interventions
NEE 15ug/min group:None
Sponsors
Zhongda Hospital, Southeast University
Eligibility
Sex/Gender
Male
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged >= 18 years old; 2.Diagnosis of sepsis conforming to Sepsis 3.0 (infection + SOFA score >= 2 within 24 hours of ICU admission.; 3.Requirement for vasoactive drugs with a usage duration > 24 hours (norepinephrine, epinephrine, dobutamine, or dopamine.; 4.Initiation of enteral nutrition (EN. within 24 hours; 5.Informed consent obtained
Exclusion criteria
Exclusion criteria: 1.Less than 3 months after gastrointestinal surgery; 2.Intestinal function not recovered after gastrointestinal surgery; 3.Presence of gastrointestinal anatomical abnormalities at this admission (e.g., intestinal perforation, mechanical intestinal obstruction, etc..; 4.Acute gastrointestinal diseases within the past 1 month (e.g., gastrointestinal bleeding.; 5.Presence of chronic gastrointestinal diseases (e.g., uncontrolled intestinal tuberculosis, Crohn's disease, etc..; 6.Pancreatitis; 7.Specific nutritional needs, such as long-term home enteral nutrition; 8.Contraindications for enteral nutrition considered by the physician: 9.Vasoactive drug use duration < 24 hours; 10.Pregnant or lactating women; 11.Adults under legal guardianship; 12.Terminally ill patients or those expected to die within 24 hours
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Enteral Feeding Intolerance Incidence; | — |
Secondary
| Measure | Time frame |
|---|---|
| 28-day mortality rate, In-ICU mortality rate, In-hospital mortality rate;Plasma citrulline concentration on Day 1/Day 3/Day 7, Plasma intestinal fatty acid-binding protein (I-FABP) concentration on Day 1/Day 3/Day 7;Mesenteric vascular resistance on Day 1/Day 3/Day 7; | — |
Countries
China
Contacts
Public ContactMo Min
Zhongda Hospital, Southeast University
Outcome results
None listed