Hypertensive disorders in pregnancy include: 1. Hypertension in pregnancy, 2. Preeclampsia, 3. Eclampsia, 4. Chronic hypertension during pregnancy, 5. Chronic hypertension complicated with preeclampsia.
Conditions
Interventions
Unexposed hypertensive disorder complicating pregnancy group:Pregnant women and their offspring who were not exposed to hypertensive disorders complicating pregnancy were selected as study subjects
Exposed hypertensive disorder complicating pregnancy group:Maternal and offspring with hypertensive disorders complicating pregnancy were selected as the research objects
Sponsors
The Second Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
16 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.Singleton; 2.Children survive beyond 5 years of age; 3.Pregnant women with or without hypertensive disorders of pregnancy; 4.There were no obvious mental disorders in the immediate family members of the third generation;
Exclusion criteria
Exclusion criteria: 1.Multiple births; 2.Stillbirth; 3.Children surviving before 5 years of age; 4.The mother of the offspring had severe heart disease; 5.The mother of the offspring has serious life-threatening diseases other than hypertensive disorders of pregnancy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Neurodevelopmental disorders (such as autism, mental retardation, cerebral palsy, visual and auditory impairment, delayed language development, etc.);Psychomotor Development Index (PDI);Cognitive Development Index (CDI);Changes in metabolism and transcriptomics;The height and head circumference of the offspring;Mental Development Index (MDI); | — |
Secondary
| Measure | Time frame |
|---|---|
| The blood pressure level of the parturient;Head circumference at birth of the offspring, cranial index (CI), median CI (minimum - maximum);The duration of breastfeeding;Infant clinical risk index;delivery mode;The weight, height and head circumference of the infant when discharged from the NICU;The birth length of the offspring;Whether the parturient has other complications (placenta previa, placental abruption, massive hemorrhage, umbilical cord prolapse);Birth weight of the offspring;Gestational age at delivery (weeks + days);The number of offspring;Dosage and timing of medication for parturients;Birth weight of the offspring;The age, height and weight of the parturient at delivery, comorbidities of the parturient, previous surgical history of the parturient, previous medication history of the parturient, years of educatio;The length of hospital stay in the neonatal NICU; | — |
Countries
China
Contacts
Public ContactHuXianwen
The Second Hospital of Anhui Medical University
Outcome results
None listed