Painless gastroscopy for elderly patients
Conditions
Interventions
Group RL1:Remimazolam tosilate + lidocaine (1.0 mg/kg)
Group RL2:Remimazolam tosilate + lidocaine (0.5 mg/kg)
Group RN:Remimazolam tosilate + normal saline
Group R:Optimal dose of remimazolam tosilate + 0.5 mg/kg lidocaine
Group B:Propofol 1.5 mg/kg + lidocaine 0.5 mg/kg
Sponsors
Ya 'an People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1Age>= 65 years; 2. BMI 18–28 kg/m^2; 3.ASA physical status class I~II.
Exclusion criteria
Exclusion criteria: 1. Preoperative systolic blood pressure>= 180 mmHg or diastolic blood pressure>= 110 mmHg or heart rate>= 110 beats/min; 2 .History of hypersensitivity to the trial drugs; 3.History of neurological disorders or inability to communicate normally; 4. Long-term use of sedative/analgesic medications; 5 .Patient or family members declined to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective Dose 50%(ED50) and Effective Dose 95%(ED95) of remimazolam tosilate;Number of patients with MOAA/S score<=2 after drug administration; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of patients with Modified Observer's Assessment of Alertness/Sedation Scale(MOAA/S score) >2 after administration;Blood pressure;Heart rate;Injection pain;Malignant, vomiting;Oxygen saturation;Inspection duration;Duration of wakefulness;Fatigue degree score;Patient and doctor satisfaction scores; | — |
Countries
China
Contacts
Public ContactYang Zhuo Xuan
Ya 'an People's Hospital
Outcome results
None listed