Stroke, Brain injury
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Clinical diagnosis of ischemic or hemorrhagic stroke, or moderate-severe traumatic brain injury (GCS initial score <=12); 2. The first onset of the disease, the course of the disease is within 3 months; 3. Muscle loss (MMT<=4) due to neurological deficits (hemiplegia/quadriplegia, balance disorders, consciousness disorders, etc.), which is regarded as the need for long-term bed rest; 4. Stable vital signs;
Exclusion criteria
Exclusion criteria: 1. Combined with severe cardiopulmonary diseases (such as NYHA cardiac function grade III-IV, COPD GOLD grade 3-4), severe liver and kidney insufficiency, active malignant tumors; 2. Fractures, severe arthritis, infections, skin breakdowns, etc., in the upper limbs or trunk that affect the assessment or training; 3. Previous history of neuromuscular diseases affecting upper limb function (such as muscular dystrophy, motor neuron disease); 4. Severe mental illness and inability to cooperate with assessment and training; 5. Presence of severe spasticity (modified Ashworth scale >=grade 3) or contractures, with significant limitation of passive activities; 6. Planned surgical or medication modification that may significantly affect muscle status during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Muscle thickness and mass were measured by ultrasound;Cough peak flow value; | — |
Secondary
| Measure | Time frame |
|---|---|
| Modified Barthel Index; | — |
Countries
China
Contacts
The Second Affiliated Hospital of Kunming Medical University