Knee Pathologies
Conditions
Interventions
Opioid-sparing group:Prior to general anesthesia induction, epidural catheterization was performed at L2-3 interspace with administration of 4 mL test dose (0.1% lidocaine). Successful placement was c
Control group:The anesthesia management involved routine induction followed by maintenance with standard-dose remifentanil (0.15-0.3 µg·kg?1·min?1), sevoflurane, and cisatracurium besylate, with suppl
Sponsors
Jinjiang Municipal Hospital
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for elective total knee arthroplasty (TKA); 2.Aged 60–80 years; 3.Body mass index (BMI) 18–29 kg/m^2; 4.American Society of Anesthesiologists (ASA) physical status class I–III; 5. The duration of operation no more than 2 h.
Exclusion criteria
Exclusion criteria: 1. Contraindications to epidural puncture and contraindications to drugs used in the study; 2. Take analgesic drugs 3 months before surgery; 3. Patient refusal.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale, VAS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative mean arterial pressure;Intraoperative heart rate;Blood Glucose ;C-reactive protein;Interleukin-6;First Ambulation Time;Adverse effects; | — |
Countries
China
Contacts
Public ContactWei Yuanyuan
Jinjiang Municipal Hospital
Outcome results
None listed