Postoperative cognitive dysfunction, POCD
Conditions
Interventions
Esketamine group :Esketamine was administered intravenously at a dose of 0.2 mg/kg
Control group:Intraoperative normal saline infusion
Sponsors
People's Hospital of Fuyang City
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1)Age >=65 years, no gender restriction; 2)ASA physical status classification: I-III; 3)Preoperative diagnosis of hip fracture, including intertrochanteric fracture, femoral trochanteric fracture, or femoral neck fracture; 4)Intact autonomous ability, clear consciousness, and ability to cooperate with the study protocol.Mini-Mental State Examination (MMSE) score >=23;Formal education duration >6 years.
Exclusion criteria
Exclusion criteria: 1)Patients with a history of psychiatric or neurological disorders, or those taking related medications; 2)Patients with a history of myocardial infarction or cerebrovascular accident; 3)Patients with severe respiratory or circulatory system diseases, or preoperative biochemical tests indicating renal dysfunction (serum creatinine >177 µmol/L) or active liver disease; 4)Patients who refused the study protocol or requested changes to the anesthesia method; 5)Patients lost to follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE score;QoR-15 score; | — |
Secondary
| Measure | Time frame |
|---|---|
| RASS score;VAS score;Heart rate;Blood pressure;Oxygen saturation, SPO2;Length of PACU stay;Rescue analgesic use;Occurrence of adverse reactions during the use of analgesic pump; | — |
Countries
China
Contacts
Public ContactYang Fangfang
People's Hospital of Fuyang City
Outcome results
None listed