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Study on brain network changes in epilepsy patients before and after provocation tests

Study on brain network changes in epilepsy patients before and after provocation tests

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104375
Enrollment
Unknown
Registered
2025-06-16
Start date
2025-05-16
Completion date
Unknown
Last updated
2025-06-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy

Interventions

Test Group 1 [Basic physiological provocation tests (eye opening/closing and hyperventilation test)]:None
Test Group 2 [Sensory provocation tests (light, auditory, and acupuncture stimulation tests)]:None
Test Group 3 [Chemical stimulation provocation tests (caffeine and alcohol intake)]:None

Sponsors

Zhongshan Hospital, Fudan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged between 18 and 65 years; 2. Diagnosed with epilepsy according to the International League Against Epilepsy (ILAE) criteria; 3. Hospitalized in the Department of Neurology at Zhongshan Hospital, Fudan University, for seizure monitoring.

Exclusion criteria

Exclusion criteria: 1. Severe cognitive impairment; 2. Pregnant or breastfeeding women; 3. Severe cardiopulmonary diseases; 4. Poor general health condition that prevents completion of the provocation test.

Design outcomes

Primary

MeasureTime frame
Changes in EEG functional connectivity network parameters;

Secondary

MeasureTime frame
Differences in the effects of different evocation modalities on brain networks in patients with different types of epilepsy;Characterization of changes in brain network hub nodes;Characterization of modular changes in brain networks;Correlation between changes in brain network topology induced by evoked tests and seizure risk;Differences and complementarities between scalp EEG and SEEG in network assessment;

Countries

China

Contacts

Public ContactJing Ding

Zhongshan Hospital, Fudan University

mao.lingyan@zs-hospital.sh.cn+86 21 6404 1990

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026