Adolescent depression
Conditions
Interventions
Diagnostic tests - control group:none
Drugs + individualised exercise group:drugs and individualised exercise
local norm:none
Diagnostic tests - case group:none
Drugs + usual care group:drugs and Routine care for depression
Sponsors
Peking University Sixth Hospital ( Institute of Mental Health )
Eligibility
Sex/Gender
All
Age
12 Years to 19 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for the case group in Study 1 : 1. patients who met DSM-5 diagnostic criteria for depressive disorders, with a clinical diagnosis made by two practicing psychiatrists, one of whom was an attending physician and the other an associate or chief physician; 2. aged 12-19 years; 3. total HAMD-17 score >=14 at baseline for enrolment; 4. patients or their guardians voluntarily submitted to the test and signed the informed consent for the study; 5. literacy skills to complete the questionnaire and psychological assessment. Inclusion criteria for the control group in Study 1 : 1. aged 12-19 years; 2. total HAMD-17 score =4 total score on the Chalder fatigue scale, with a No change in CGI efficacy score within 2 weeks; 5. No regular exercise in the past and no modified electroconvulsive therapy within 6 months; 6. Patients and guardians voluntarily accepted the test and signed the informed consent for the study.
Exclusion criteria
Exclusion criteria: The case group exclusion criteria for Study 1 : 1. Clinical diagnosis by two practicing psychiatrists, one of whom was an attending physician and the other an associate or chief physician, of other psychiatric disorders that met the DSM-5 diagnostic criteria, including organic mental disorders, psychoactive substance-induced psychiatric disorders, schizophrenia, bipolar disorders, intellectual disorders, and autism spectrum disorders (with the anxiety disorders Exceptions); 2. Patients with a history of severe neurological disorders (including seizures, brain injury, multiple sclerosis, degenerative diseases such as acute lateral sclerosis, Parkinson's disease, and movement disorders); 3. Patients currently suffering from serious unstable physical illnesses such as diabetes mellitus, thyroid disorders, hypertension, cardiac disease, and narrow-angle glaucoma. The control group exclusion criteria in Study 1: 1. clinical diagnosis by two practicing psychiatrists to exclude patients with bipolar disorder that met the DSM-5 diagnostic criteria, patients with current depressive episodes, and patients with intellectual disability; 2. history of severe neurological disorders (including seizures, brain injury, multiple sclerosis, degenerative diseases such as acute lateral sclerosis, Parkinson's disease, and movement disorders) in the Patients; 3. Currently suffering from serious unstable physical illnesses such as diabetes mellitus, thyroid disease, hypertension, cardiac disease, and narrow-angle glaucoma. The exclusion criteria for Study 2 : 1. any mental disorder that meets the DSM-5 diagnosis or a first-degree relative with a previous mental disorder or inherited neurological disease; 2. patients with a history of severe cranio-cerebral trauma that triggered a loss of consciousness either currently or in the past, and the presence of cognitive impairment and mental retardation. The exclusion criteria for Study 3 : 1. other mental disorders that met the DSM-5 diagnostic criteria, including organic mental disorders, psychoactive substance-induced psychiatric disorders, schizophrenia, bipolar disorder, and autism spectrum disorders; 2. current or previous comorbid neurological disorders or other serious somatic disorders, serious cardiovascular and cerebrovascular disorders, and serious respiratory disorders that preclude the acceptance of exercise; 3. Current or previous history of substance abuse or dependence, family history of mental illness; 4. Current or previous history of severe craniocerebral trauma that triggered loss of consciousness, patients with cognitive impairment, intellectual disability; 5. Contraindications to magnetic resonance examination.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fatigue;sensitivity;specificity;ROC curve; | — |
Secondary
| Measure | Time frame |
|---|---|
| Subjective cognitive functions;Insomnia;social function;Anhedonia;depressive symptoms;burden of disease;Non-Suicidal Self-injury;depressive symptoms;Clinical efficacy;quality of life;cognitive function;drowsiness;physical activity level; | — |
Countries
China
Contacts
Public ContactChuan Shi
Peking University Sixth Hospital ( Institute of Mental Health )
Outcome results
None listed