refractory septic shock
Conditions
Interventions
HA380 hemoperfusion group:Administer HA380 hemoperfusion
Control group:None
Sponsors
The First People's Hospital of Lianyungang City
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with septic shock =200 pg/ml; 3.Age between 18 and 80 years old (inclusive); 4.The patient or family member has a full understanding of the purpose and significance of this trial, voluntarily agrees to participate in this clinical trial, and signs the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.Patients with immunocompromise: ? Primary immunodeficiency diseases; ? Recipients of solid organ or bone marrow transplants; ? Patients receiving corticosteroid therapy at a daily dose>=20 mg prednisone or equivalent for >=14 days, or with a cumulative prednisone dose of 600 mg; ? Patients with malignant tumors undergoing chemotherapy; ? Patients receiving other immunosuppressive drugs (e.g., cyclosporine, cyclophosphamide, hydroxychloroquine, methotrexate); 3.Patients with coagulation disorders, active bleeding, or uncontrollable acute massive hemorrhage (within 24 hours); 4.Patients with malignant tumors and/or wasting diseases, those unable to undergo focus debridement (e.g., surgical patients unable to undergo operation), or those with low body weight (<35 kg); 5.Platelet count <20×10?/L; 6.Patients with a predicted mortality within 24 hours; 7.Patients who have participated in or are currently participating in any clinical study within the past month; 8.Other conditions deemed unsuitable for enrollment by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The degree of dependence on vasoactive drugs in critically ill patients; | — |
Secondary
| Measure | Time frame |
|---|---|
| The degree of organ dysfunction or failure in critically ill patients;Blood interleukin-6 and procalcitonin;mortality rate;Mortality rate in the intensive care unit;In-hospital mortality rate;The duration of stay in the intensive care unit;Length of hospital stay ;ventilator-free days; | — |
Countries
China
Contacts
Public ContactKang Xiuwen
The First People's Hospital of Lianyungang City
Outcome results
None listed