Disorder: Obstructive Sleep Apnea Syndrome (OSA)Symptoms
Conditions
Interventions
Placebo Group:Intravenous normal saline administration
Dimetline Group:Intravenous Dimetline administration
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 65 years; 2.ASA physical status classification I-III; 3.Scheduled to undergo uvulopalatopharyngoplasty (UPPP); 4.Voluntarily provided written informed consent;
Exclusion criteria
Exclusion criteria: 1.Severe cardiopulmonary comorbidities (e.g., recent myocardial infarction, cardiac insufficiency, severe COPD, asthma); 2.Abnormal hepatic/renal function(Alanine aminotransferase (ALT) >100 U/L?Aspartate aminotransferase (AST) >100 U/L?Serum creatinine >115 µmol/L); 3.High-risk procedures requiring postoperative ICU admission or anticipated difficult extubation; 4.History of myasthenia gravis or other neuromuscular disorders; 5.Hematologic diseases or hemorrhagic disorders; 6.Known hypersensitivity to Dimetline; 7.Pregnancy or lactation; 8.Psychiatric disorders, epilepsy, alcohol/drug abuse, or neurological conditions affecting assessment; 9.Declined to participate in the study; 10.Concurrent enrollment in other clinical trials;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extubation time; | — |
Secondary
| Measure | Time frame |
|---|---|
| Arterial blood gas monitoring;Inflammatory markers;Spontaneous breathing recovery time;Postoperative hypoxemia incidence rate;Quality of Recovery in the Post-Anesthesia Care Unit (QoR-PACU2) score;Postoperative return to ward time;Ramsay score;NRS score;SAS score; | — |
Countries
China
Contacts
Public ContactLuo Yan
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed