Postoperative analgesia in ICU patients with mechanical ventilation
Conditions
Interventions
Control group:Remifentanil Injection
Sponsors
Jiangdu People's Hospital Affiliated to Yangzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 85 years old (inclusive); 2.Body mass index (BMI) ranging from >18 kg/m² to <30 kg/m²; 3.Postoperative mechanically ventilated patients admitted to the ICU with an expected mechanical ventilation duration of more than 12 hours; 4.Hemodynamic stability.
Exclusion criteria
Exclusion criteria: 1.History of opioid allergy; 2.Long-term use of analgesic medications; 3.Neuropsychiatric disorders requiring pharmacologic treatment; 4.Comorbid craniocerebral injury and/or cerebrovascular accident; 5.Neuromuscular blocking therapy; 6.Cognitive impairment; 7.Brain death or vegetative state; 8.Pregnancy; 9.Participation in another study within the past 30 days; 10.Abnormal liver or kidney function (aspartate aminotransferase [AST] and/or alanine aminotransferase [ALT] and/or total bilirubin [TBiL] >=2× upper limit of normal [ULN]; serum creatinine [Cr] >= 2× ULN, or patients receiving renal replacement therapy); 11.History of drug abuse and/or alcoholism within the past 3 months, where alcoholism is defined as an average daily alcohol consumption > 2 units (1 unit = 360 ml of 5% beer, 45 ml of 40% liquor, or 150 ml of wine); 12.Patients with severe respiratory distress after intubation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Critical Care Pain Observation Tool ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Equivalent morphine dose;Daily Awakening Time;Blood Pressure;Heart Rate;Respiratory Rate(RR);Vasoactive Drug Dosage;The length of stay in ICU;The total length of hospitalization;The incidence rate of adverse events;CPOT score during extubation;The incidence rate of arrhythmia;28-day mortality rate;Duration of mechanical ventilation; | — |
Countries
China
Contacts
Public ContactYuan Jun
Jiangdu People's Hospital Affiliated to Yangzhou University
Outcome results
None listed