Postoperative Pain and Negative Affective States
Conditions
Interventions
Group F:Postoperative analgesia was achieved with continuous sufentanil infusion
(2 µg/kg total dose administered over 48 hours, diluted in 0.9% saline to a total volume of 150 mL via intravenous pump
Group S1:Postoperative analgesia was administered via combined sufentanil-esketamine infusion
(Sufentanil 2 µg/kg + Esketamine 0.5 mg/kg total doses administered over 48 hours, constituted in 0.9% sal
Group S2:Postoperative analgesia was delivered through a sufentanil-esketamine admixture
(Sufentanil 2 µg/kg + Esketamine 1 mg/kg total doses infused over 48 hours, diluted with 0.9% saline to final v
Group S3:Postoperative analgesia consisted of a dual-drug infusion regimen
(Sufentanil 2 µg/kg + Esketamine 2 mg/kg total doses administered continuously over 48 hours in 150 mL 0.9% saline solution)
Sponsors
The Second People's Hospital of Hefei
Eligibility
Sex/Gender
All
Age
20 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged 20-70 years; 2.American Society of Anesthesiologists (ASA) physical status classification I-III; 3.Scheduled for video-assisted thoracoscopic surgery (VATS).
Exclusion criteria
Exclusion criteria: 1.Known hypersensitivity to esketamine; 2.Unstable ischemic heart disease; 3.Elevated intracranial or intraocular pressure; 4.Severe comorbidities with impaired major organ function (e.g., hepatic, renal, cardiac); 5.History of analgesic substance abuse; 6.Severe dementia, communication barriers, or diagnosed psychiatric disorders; 7.Body mass index (BMI) >35 kg/m²; 8.Intraoperative conversion to open thoracotomy; 9.Refusal or inability to use patient-controlled intravenous analgesia (PCIA) devices; 10.Anticipated surgical duration <1 hour.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Moderate-to-Severe Postoperative Pain within 48 Hours after Surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum amyloid A;C reactive protein;tumor necrosis factor-alpha;interleukin - 6;Total Opioid Consumption within 72 Hours Postoperatively;brain-derived neurotrophic factor,BDNF;Hospital anxiety and depression scale;State-Trait Anxiety Inventory;surgical fear question naire;Pain Catastrophizing Scale;Incidence of Adverse Events;ncidence of chronic pain; | — |
Countries
China
Contacts
Public ContactHongjian Wang
The Second People's Hospital of Hefei
Outcome results
None listed