Early Esophageal Cancer
Conditions
Interventions
Experimental group:Autologous rectal mucosal oesophageal transplantation
Control group: Inject Triamcinolone Acetonide
Sponsors
Department of Gastroenterology, Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18-75 years old, gender not limited; 2. Early esophageal cancer or precancerous lesions, with an area greater than or equal to 3/4 of the circumference and a length greater than or equal to 3cm, or circumferential lesions; 3. Comply with ESD indications; 4. The rectal mucosa is normal, without ulcers or tumors. 5. Voluntarily accept and abide by this experimental protocol, undergo re-examination and follow-up on time, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Combined with esophageal or rectal varicose veins or hemangiomas; 2. Combined with digestive tract lumen stenosis, the endoscope body cannot be inserted. 3. Individuals with severe anemia (hemoglobin =18 seconds), those suffering from bleeding disorders, and those taking oral anticoagulant or antiplatelet drugs who have not been able to stop taking the drugs for the required 5-7 days before the operation as per the guidelines, or who are unable to stop taking the drugs due to their own health conditions; 4. Those with severe heart diseases (NYHA grade >= Grade IV) or lung diseases who are unable to tolerate painless gastroscopy and colonoscopy treatment; 5. Women who are pregnant or breastfeeding at the time of screening; 6. Those who have participated in other clinical trials within three months prior to the trial; 7. Other circumstances where the researcher deems the candidate unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative stenosis and grade of dysphagia;Incidence of refractory oesophageal strictures after surgery;Complications of surgery: perforation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of dilations;Duration of surgery;Length of hospital stay;Total cost;Infection;Fistula;Bleeding; | — |
Countries
China
Contacts
Public ContactChaoqiang Fan
Department of Gastroenterology, Second Affiliated Hospital of Army Medical University
Outcome results
None listed