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The influence and mechanism of comorbidity of obstructive sleep apnea and depression on metabolic syndrome

The influence and mechanism of comorbidity of obstructive sleep apnea and depression on metabolic syndrome

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2500104300
Enrollment
Unknown
Registered
2025-06-13
Start date
2022-03-01
Completion date
Unknown
Last updated
2025-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

obstructive sleep apnea

Interventions

depression group:none
health control group:none
OSA comorbid with depression group:none

Sponsors

West China Hospital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
40 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Women aged 40 to 70; 2. presence of snoring; 3. No antidepressants, antipsychotic drugs, mood stabilizers, benzodiazepines or other drugs affecting the central nervous system have been used for at least 3 months before the first episode or enrollment. 4. Voluntary participation in the study with written informed consent obtained from the participant;

Exclusion criteria

Exclusion criteria: 1. Individuals with severe, poorly controlled, or unstable medical conditions deemed unsuitable for this study by the investigators, such as atrial fibrillation; 2. Individuals who meet the DSM-V diagnostic criteria for other psychiatric disorders, such as substance dependence or schizophrenia; 3. Individuals with a history of any neurological disorders, including traumatic brain injury, seizures, or neurodegenerative diseases; 4. Individuals who have undergone hysterectomy or bilateral oophorectomy; 5. Individuals who have received estrogen replacement therapy within the past 3 months; 6. Individuals currently receiving treatment for OSA within the past 3 months; 7. Individuals with comorbid sleep disorders, such as narcolepsy, restless legs syndrome, or REM sleep behavior disorder.

Design outcomes

Secondary

MeasureTime frame
Collection of general demographic and clinical data;The severity of depression;sleep structure related parameters;fasting blood glucose and glycosylated hemoglobin;sex hormone;Lipid profile;Measurement of physical parameters;blood pressure;inflammatory factor;

Countries

China

Contacts

Public ContactTaomei Li

West China Hospital of Sichuan University

1401392396@qq.com+86 28 85422825

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026