Breast Cancer
Conditions
Interventions
Mg-OA-PBI group:Online adaptive partial breast irradiation guided by magnetic resonance imaging
Sponsors
Peking Union Medical Hospital
Eligibility
Sex/Gender
Female
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Female, aged >= 40 years old; 2. ECOG status grading 0-1 points; 3. Within 8 weeks after unilateral breast conserving surgery; 4. Invasive breast cancer confirmed by pathology shall meet at least 2 of the following conditions: a) tumor size <= 2cm (pT1, see Appendix I) b) histological grading 1-2; c) ER positive (if only b and c are met, the tumor size must be <= 3cm); 5. breast ductal carcinoma in situ confirmed by pathology, which must meet at least one of the following conditions: a) histological grade 1-2; b) Tumor size <= 2cm (if only a is met, tumor size must be <= 3cm); 6. HER-2 positive patients who are expected to receive HER2 targeted therapy for 1 year; 7. ER positive patients who are expected to receive endocrine therapy for 5 years; 8. sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Lymph node positivity; 2. Positive cutting edge; 3. HER-2 positive but not receiving HER-2 targeted therapy; 4. ER positive but not receiving endocrine therapy; 5. Lymphatic vessel infiltration; 6. Invasive lobular carcinoma of the breast; 7. BRCA 1/2 mutation; 8. After neoadjuvant therapy; 9. The breast tumor bed cannot be identified in the localization image; 10. There are pacemakers, claustrophobia, and other conditions in the body that cannot undergo MRI examination; 11. Serious underlying diseases; 12. Severe hematopoietic dysfunction, heart, lung, liver, kidney dysfunction, and immune deficiency; 13. Individuals with neurological or psychiatric disorders that affect cognitive abilities.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early radiation injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Breast appearance effect;Quality of life;Ipsilateral breast tumor recurrence rate;Disease-Free Survival (DFS);Overall survival;Late radiation injury; | — |
Countries
China
Contacts
Public ContactHou Xiaorong
Peking Union Medical College Hospital
Outcome results
None listed