Systemic sclerosis
Conditions
Interventions
Case group:None
Control group:None
Sponsors
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. SSc patient selection: (1) Patients must meet the classification criteria for systemic sclerosis established by the American College of Rheumatology (ACR) in 1980 or the American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) in 2013; (2) The age of the patient should be greater than or equal to 18 years old at the time of enrollment; 2. Selection of healthy volunteers: Healthy volunteers must be aged 18 years or older and have no history of acute or chronic infection.
Exclusion criteria
Exclusion criteria: 1. SSc patients: (1) Significant health problems or diseases, including (but not limited to) the following: poorly controlled hypertension (>=160/95 mmHg), congestive heart failure (New York Heart Association criteria class III or IV), poorly controlled diabetes mellitus or poor functional status that makes it impossible to take care of oneself, other autoimmune diseases, tumors; (2) The total number of peripheral blood leukocytes =160/95 mmHg), congestive heart failure (New York Heart Association criteria class III or IV), poorly controlled diabetes mellitus or poor functional status that makes it impossible to take care of oneself, other autoimmune diseases, tumors; (2) The total number of peripheral blood leukocytes < 3 000 /µL, or the < platelets 100 000 /µL or the neutrophil < 1 500 /µL or the hemoglobin < 85 g/L at screening; (3) Pregnant, pregnant or lactating women; (4) Current infection, chronic or recurrent infectious diseases, or evidence of latent tuberculosis infection; (5) Known infection with human immunodeficiency virus, hepatitis B virus or hepatitis C virus at the time of screening; (6) Any other conditions that the investigator considers unsuitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Decorolican; | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral blood mononuclear cell;Cytockines; | — |
Countries
China
Contacts
Public ContactLingli Dong
Tongji Hospital, Tongji Medical College ,Huazhong University of Science and Technology
Outcome results
None listed