Rebound pain after peripheral nerve block
Conditions
Interventions
Group high DEX:Intravenous injection of 0.3mg/kg dexamethasone
Group R:Intravenous injection of saline
Group low DEX:Intravenous injection of 0.1mg/kg dexamethasone
Sponsors
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.ASA I-III; 2. Age >=18 years old; 3.BMI 18-30kg/m^2 (minimum weight 50kg); 4. Patients scheduled for unilateral knee arthroplasty; 5. The procedure should last no more than 3 hours.
Exclusion criteria
Exclusion criteria: 1. Secondary total knee arthroplasty; 2. Any contraindications or allergies to the drugs used in the trial; 3. Long-term use of opioids or systemic corticosteroids; 4. Drug or alcohol abuse; 5. Patients with diabetes mellitus; 6. ASA grade IV-V; 7. Pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of rebound pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| The difference in pain scores before and after the disappearance of CFSNB analgesic effect;The occurrence time of rebound pain;Duration of rebound pain;Postoperative pain score;Usage of PCIA Fentanyl;The dosage of rescue analgesics used within 48 hours after surgery;Sleep disorders caused by postoperative pain at the surgical site;Adverse events;Nausea and Vomiting;Urinary Retention; | — |
Countries
China
Contacts
Public ContactCongjie Bi; Siru Li
Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital)
Outcome results
None listed