Radiation-induced oral mucositis is characterized by ulcerative lesions in the oral and pharyngeal mucosa accompanied by persistent severe pain, which impairs swallowing and speech functions. This condition subsequently leads to malnutrition, dependence on analgesic medications, prolonged hospitalization, and increased financial burden. It is recognized as one of the most debilitating adverse effe
Conditions
Interventions
Intervention group:Standardized Care Bundle for Prevention of Radiation-Induced Oral Mucositis
Sponsors
The University of Hongkong - Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.Age >=18 years. 2.Patients with histopathologically confirmed primary head and neck cancer scheduled to receive radiotherapy with a prescribed course of 30-35 fractions. 3.Patients who were fully informed of their diagnosis and voluntarily consented to participate in this study after detailed explanation by investigators.
Exclusion criteria
Exclusion criteria: 1.Patients with impaired consciousness or communication/comprehension difficulties. 2.Patients with severe mental disorders or serious somatic diseases. 3.Patients with diabetes mellitus or honey product allergies. 4.Currently participating in other similar clinical studies. 5.Patients receiving concurrent radiotherapy with immunotherapy or targeted therapy. 6.Pre-existing oral mucositis prior to radiotherapy initiation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and severity of radiation-induced oral mucositis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life Assessment;Time to onset of most severe radiation-induced oral mucositis;Nasogastric Tube Insertion Rate; | — |
Countries
China
Contacts
Public ContactZhou Jie
The University of Hongkong - Shenzhen Hospital
Outcome results
None listed