Insomnia Disorder
Conditions
Interventions
Experimental group:Propofol administration for anesthesia induction
Sponsors
Chongqing Seventh People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 65 years; 2.Classified as American Society of Anesthesiologists ASA. Physical Status I–III; 3.Diagnosed with chronic insomnia with poor response to conventional pharmacological treatment benzodiazepine receptor agonists and other medications such as melatonin or melatonin receptor agonists. within the 3 months prior to baseline; 4.Received a stable dose of sedative-hypnotic and/or antidepressant or anxiolytic medication within 2 weeks prior to baseline; 5.Meet the diagnostic criteria for chronic insomnia disorder according to the International Classification of Sleep Disorders, Third Edition ICSD-3., including: (1).At least one of the following nighttime symptoms: difficulty initiating sleep, difficulty maintaining sleep, early morning awakening, resistance to going to bed at an appropriate time, or needing a caregiver to initiate sleep; (2).At least one daytime impairment: such as fatigue, irritability, or decreased performance in work, study, or social activities; (3).Symptoms occur at least three times per week and have been present for at least three months; 6.Voluntarily choose to receive sedative-hypnotic treatment and provide written informed consent; 7.All patients with insomnia were filled in with a pre-test questionnaire package before anesthesia intervention, and basic demographic information was investigated.
Exclusion criteria
Exclusion criteria: 1. Patients with known hypersensitivity to propofol; 2. Patients with severe intellectual disability or decompensated organ dysfunction; 3. Patients experiencing acute asthma exacerbation; 4. Pregnant or lactating women; 5. Patients diagnosed with severe obstructive sleep apnea syndrome OSAS.; 6. Uncooperative patients or those who refuse to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physiological Arousal Indicators;Subjective Indicators;EEG Indicators;Inhibitory Control Behavioral Indicators;Reaction time and accuracy of emotion matching tasks; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intervention Compliance and Adverse Reactions; | — |
Countries
China
Contacts
Public ContactHuang Li
Chongqing Seventh People's Hospital
Outcome results
None listed