The effect of propofol combined with alfentanil target-controlled infusion compared with intermittent bolus injection in gastroenteroscopy

Status

Recruiting

Phases

Phase 4

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2500104208

Enrollment

Unknown

Registered

2025-06-12

Start date

2025-04-02

Completion date

Unknown

Last updated

2025-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

hypoxemia

Interventions

Target-controlled infusion group:None

Intermittent bolus group:None

Eligibility

Sex/Gender

All

Age

20 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.The patient requested a painless gastroenteroscopy; 2. Age 20-70 years old; 3. BMI: 18-28kg/m2; 4. The American Society of Anesthesiologists (ASA) grades I to III; 5. Sign the informed consent form for anesthesia;

Exclusion criteria

Exclusion criteria: 1. severe cardiovascular disease; 2. Expected difficult airway; 3. Patients with long-term opioid allergy; 4. History of alcoholism; 5. History of asthma; 6.Recent upper respiratory tract infections; 7.Fasting blood glucose = 11.1mmol/L during diabetes history or screening period; 8.Hypertensive history or screening period SBP >= 140mmHg and/or DBP >= 90mmHg; 9.Patients with high blood pressure who take reserpine; 10.A history of drug and alcohol abuse within two years before the start of the screening period; 11.History of pregnancy or breastfeeding; 12.History of hyperthyroidism; 13.Mental illness, long-term use of psychotropic drugs, and cognitive impairment; 14.Sleep apnea; 15.Chronic lung diseases; 16.History of epilepsy; 17.Have severe hepatorenal insufficiency; 18.Patients who have had a cerebral or myocardial infarction within 6 months.

Design outcomes

Primary

Measure	Time frame
Intraoperative incidence of hypoxemia (defined as intraoperative SpO2 < 90% greater than 30s);Intraoperative hypotension (defined as MAP < 65m, duration greater than 1 min);	—

Secondary

Measure	Time frame
MAP, HR, SpO2 at different times during anesthesia;Marker events during anesthesia (eyelash reflex disappearance time, total gastroenteroscopy time, patient recovery time, time away from the room, total propofol dosage, total alfentanil dosage);Intraoperative adverse reactions (bradycardia, apnea, injection pain, motor response, cough response);Postoperative adverse reactions (nausea, vomiting, headache, dizziness, bloating, abdominal pain, sore throat);	—

Measure

Time frame

MAP, HR, SpO2 at different times during anesthesia;Marker events during anesthesia (eyelash reflex disappearance time, total gastroenteroscopy time, patient recovery time, time away from the room, total propofol dosage, total alfentanil dosage);Intraoperative adverse reactions (bradycardia, apnea, injection pain, motor response, cough response);Postoperative adverse reactions (nausea, vomiting, headache, dizziness, bloating, abdominal pain, sore throat);

—

Countries

China

Contacts

Public ContactZhang Erfei

Affiliated Hospital of Yan'an University

zhangerfei09@126.com+86 138 9117 0975

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026