Primary nephrotic syndrome
Conditions
Interventions
Gold Standard:Gold standard: Pathogenic microorganisms can be cultured in blood, sputum, urine, etc.
Reference standard: clinical manifestations (such as fever, cough, sputum production) Imaging mani
Index test:T lymphocyte subset surveillance
Sponsors
Fifth Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
14 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 14 years and 3.5g/d); b. Hypoalbuminemia (liver function: albumin<30g/L);c. Edema; d. The blood lipid is elevated. Among them, item a and b are necessary conditions for diagnosis. 3.Renal puncture pathology suggests pathological types of nephrotic syndrome (minimal change glomerulonephropathy, membranous nephropathy, focal segmental glomerulonephritis, membranous proliferative glomerulonephritis, mesangial proliferative glomerulonephritis). 4.Clinically, glucocorticoids or corticosteroids combined with immunosuppressants are required;
Exclusion criteria
Exclusion criteria: 1.Secondary nephrotic syndrome, such as secondary to systemic lupus erythematosus, hepatitis B, hepatitis C, tumor, organic solvent , heavy metal poisoning, etc. 2.Patients with tumors and chronic infectious diseases, such as HIV infection, cardiac insufficiency, acute hepatitis, aminotransferase elevation more than 2 times the normal value, deep vein thromboembolism; 3.The subjects of the study were pregnant and lactating women. 4.Patients with serious primary diseases such as heart, brain, liver and hematopoietic system. 5.Those who are unable to cooperate, such as psychopaths. 6.Known hypersensitivity to or contraindication to any component in glucocorticoids, FK506, MMF, CTX. 7.Serum creatinine (SCr) > 265.2 micromol/L (3 mg/dl);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infection is clinically diagnosed; | — |
Secondary
| Measure | Time frame |
|---|---|
| Symptoms improve and the drug is discontinued;Significant renal failure CKD4, GFR <30ml/(min.173m2); | — |
Countries
China
Contacts
Public ContactZhu Weiping
Fifth Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed