Colorectal malignant tumor
Conditions
Interventions
Sugammadex group:After the surgery, when T2 is reproduced, Shu Geng Glucose Sodium is given
Neostigmine group:After the surgery, when T2 was reproduced, the maximum dose of neostigmine was 50ug/kg and atropine was 20ug/kg. The maximum dose of neostigmine did not exceed 5mg. When the calculat
Sponsors
Nanjing Drum Tower Hospital Group Suqian Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients aged 65 to 80 who are scheduled for laparoscopic colorectal surgery; (2) ASA classification levels I-III; (3)18.5 <=BMI< 28 kg/m 2; (4) Agree to participate in this experiment and sign the informed consent form
Exclusion criteria
Exclusion criteria: (1) Patients with expected difficult airways; (2) Patients with known or suspected neuromuscular diseases (such as myasthenia gravis, periodic paralysis, or polymyositis); (3) Diabetes patients with peripheral neuropathy; (4) Patients with a history of malignant hyperthermia or family history; (5) Patients taking anticonvulsants, magnesium, or certain antibiotics (such as gentamicin, neomycin, polymyxin, paromycin, etc.) known to interact with neuromuscular blocking agents; (6) Patients with severe liver and kidney dysfunction (ALT or AST exceeding the upper limit of normal values by more than twice, GFR<30 mL/min); (7) Patients with cardiac dysfunction (NYHA = 3), bradycardia, and ventricular tachycardia; (8) Patients who are allergic to research drugs or anesthetics; (9) Patients who have participated in other clinical studies within the past 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pulmonary complications; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of residual neuromuscular blockade;The incidence of postoperative nausea and vomiting;Incidence of postoperative bradycardia;Time to extubation;Duration of PACU stay;The time of first exhaust and defecation and the time of first ambulation;Length of Postoperative Hospital Stay;Postoperative Pain Score; | — |
Countries
China
Contacts
Public ContactGuixiang Zhang
Nanjing Drum Tower Hospital Group Suqian Hospital
Outcome results
None listed