Postoperative analgesia after gynecological single-port surgery
Conditions
Interventions
LB:Under ultrasound guidance, bilateral QLB was performed at the subcostal region through the posterior approach. 30 ml of 0.44% bupivacaine liposome was injected on each side.
NC:Under ultrasound guidance, bilateral QLB was performed at the subcostal region through the posterior approach. 30 ml of normal saline was injected into each side.
Sponsors
The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria: a. Age 18-65 years old, ASA classification I-II level b. Planned for elective gynecological single-port laparoscopic surgery (such as ovarian cystectomy, total hysterectomy, bilateral adnexectomy, etc.) c. Voluntarily sign the informed consent form
Exclusion criteria
Exclusion criteria: Exclusion criteria: a. History of local anesthetic allergy or opioid dependence; b. Coagulation dysfunction (INR > 1.4, PLT 3 months; d. Severe heart or lung diseases or liver and kidney dysfunction; e. Long-term use of opioids or glucocorticoids (> 3 months, prednisone = 5mg/d equivalent dose); f. Presence of cognitive impairment preventing the operation of PCIA equipment; g. Pregnant or lactating women; h. Surgery duration > 180 minutes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total consumption of oxycodone (mg) 72 hours after surgery;Number of PCIA compressions and the time of the first compression (in postoperative hours); | — |
Secondary
| Measure | Time frame |
|---|---|
| The area under the curve of the resting/moving NRS score within 72 hours after the operation;The intraoperative dosage of remifentanil/sufentanil and the dosage of oxycodone in the recovery room (in µg/kg/h);The change gradient of the QoR-15 score at 24/48/72 hours;Dynamic changes in serum IL-6/TNF-a levels;First defecation/elimination time (hours);Abdominal distension score (0 - 10 points); | — |
Countries
China
Contacts
Public ContactMa Rong
The First Affiliated Hospital of Nanjing Medical University, Jiangsu Provincial Hospital
Outcome results
None listed