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A non-inferiority study of the effect of collagen matrix (Mucograft) as a soft tissue management substitute for autogenous connective tissue grafting in the preservation of alveolar ridge in the esthetic area of the anterior teeth

A non-inferiority study of the effect of collagen matrix (Mucograft) as a soft tissue management substitute for autogenous connective tissue grafting in the preservation of alveolar ridge in the esthetic area of the anterior teeth

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104152
Enrollment
Unknown
Registered
2025-06-11
Start date
2025-06-16
Completion date
Unknown
Last updated
2025-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentition defects

Interventions

control group:Post-extraction soft tissue enhancement using autologous palatal soft tissue grafts
test group:The test group used a collagen matrix (mucograft) for post-extraction soft tissue enhancement

Sponsors

Beijing Stomatological Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1) Single maxillary anterior tooth requiring extraction due to dental caries, pulpal complications, trauma, or other conditions rendering the tooth non-restorable, where implant-supported restoration is selected as the treatment option, and natural teeth are present on both adjacent sides; 2) Patients aged 18 to 65 years, regardless of gender; 3)Good oral hygiene, with plaque index (PI) < 2 and bleeding on probing (BOP) at < 20% of sites;

Exclusion criteria

Exclusion criteria: 1) Active or uncontrolled periodontal disease (probing depth >= 4mm), or acute infection at the target site; 2) Smoking (> 10 cigarettes/day); 3) Contraindications for surgical procedures or history of head and neck radiotherapy, or uncontrolled systemic diseases (such as diabetes), systemic conditions or medications affecting soft and hard tissue healing (such as bisphosphonate therapy); 4) Pregnant or lactating women; 5) Individuals with mental or intellectual disabilities.

Design outcomes

Secondary

MeasureTime frame
Clinical Aesthetic Indicators;

Primary

MeasureTime frame
Lateral lip marginal bone level;Thickness of the lateral labial plate;Lateral lip at the level of the central mucosa;Lateral lip keratinized gingival width;Lateral lip keratinized gingival thickness;Lateral Labial Soft Tissue Blood Perfusion Levels;The ratio of type I collagen/type III collagen in labial gingiva;Patient satisfaction (VAS);

Countries

China

Contacts

Public ContactYang Tao

Beijing Stomatological Hospital, Capital Medical University

oyt0624@163.com+86 176 0090 6240

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026