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A prospective randomized controlled study of liposomal bupivacaine in ultrasound-guided pericapsular nerve group block

A prospective randomized controlled study of liposomal bupivacaine in ultrasound-guided pericapsular nerve group block

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104130
Enrollment
Unknown
Registered
2025-06-11
Start date
2025-07-01
Completion date
Unknown
Last updated
2025-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative analgesia after hip arthroplasty

Interventions

experimental group:Pericapsular nerve group block was performed before hip arthroplasty using 133 mg bupivacaine liposome + 50 mg bupivacaine hydrochloride + normal saline (total volume 20 ml).
control group:Pericapsular nerve group block was performed before hip arthroplasty using 266 mg bupivacaine liposome + normal saline (total volume 20 ml).

Sponsors

Beijing Friendship Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: ASA I-III; aged 18-80 years, requiring hip arthroplasty.

Exclusion criteria

Exclusion criteria: Patients with a history of allergy to bupivacaine or other local anesthetic drugs; Patients with severe heart, liver or kidney disease; Patients with nerve or muscle disease affecting pain perception or muscle activity; Patients with cognitive dysfunction; Pregnant women.

Design outcomes

Primary

MeasureTime frame
Morphine equivalent of opioid analgesia administered within 24 hours of surgery;

Secondary

MeasureTime frame
Morphine equivalent of opioid analgesia administered within 48 and72 hours of surgery;Additional doses of loxoprofen, Kaifu, parecoxib were administered in the ward at 24, 48, and 72 hours after surgery;Time of first pressing analgesic pump, times of pressing analgesic pump;Pain score (VAS score) at 6, 24, 48 and 72 hours after operation;Quadriceps muscle strength levels at 6, 24, 48, and 72 hours after surgery;First time out of bed after surgery;Postoperative anaesthesia-related complications;QoR-15 questionnaire at 72 hours after surgery;Pain score (VAS score) of patients during intraspinal puncture and catheterization and operation satisfaction score (using VAS score) of operators during intraspinal puncture and catheterization;

Countries

China

Contacts

Public ContactKai Su

Beijing Friendship Hospital, Capital Medical University

tubage_sk@163.com+86 135 5231 3099

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026