Gram-negative bacterial infection in critically ill patients
Conditions
Interventions
Treatment group: Receiving standard-dose polymyxin therapy.:None
Sponsors
Hainan Provincical People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Patients with intracranial infections, diagnosed based on the presence of two or more of the following criteria: (1) Positive cerebrospinal fluid (CSF) culture results; (2)Body temperature above 38°C or below 36°C, accompanied by positive meningeal irritation signs (nuchal rigidity, positive Kernig's sign, and positive Brudzinski's sign), headache, or vomiting; (3) CSF sample showing positive changes, including a white blood cell count exceeding 1,000 × 10^6 cells/L, and glucose levels below 2.2 mmol/L or less than 40% of the blood glucose level. 2. Patients who have received polymyxin for more than 4 days; 3. Adult patients aged =18 years; 4. Patients who have provided consent and signed the informed consent form; 5. Patients with continuous therapeutic drug monitoring data during the study period.
Exclusion criteria
Exclusion criteria: 1. Individuals with severe cardiac, pulmonary, or liver dysfunction (aspartate aminotransferase or alanine aminotransferase levels exceeding 40 U/L) and/or renal failure (serum creatinine levels exceeding 106 µmol/L), or those with a history of allergy to polymyxin; 2. Pregnant women; 3. Patients with incomplete or unreliable therapeutic drug monitoring data during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood concentration;Drug clearance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Healing conditions; | — |
Countries
China
Contacts
Public ContactMin Wang
Hainan Provincial People 's Hospital
Outcome results
None listed