Acute respiratory tract infection with fever
Conditions
Interventions
Control group:Ibuprofen suspension is taken first, followed by dexibuprofen suspension
Test Group:Dexibuprofen suspension is taken first, followed by ibuprofen suspension
Sponsors
children's hospital of fudan university
Eligibility
Sex/Gender
All
Age
1 Years to 6 Years
Inclusion criteria
Inclusion criteria: 1. Acute infection-induced fever in hospitalized children; 2. Children aged 1 to 6 years, inclusive, with no gender restrictions; 3. Axillary temperature >38.5°C and <40°C; 4. Normal renal function; 5. Children with acute fever within 3 days.
Exclusion criteria
Exclusion criteria: 1. Children with severe infection or those with septic shock due to various causes; 2. Children who have received corticosteroid or intravenous immunoglobulin (IVIG) treatment; 3. Children with immunodeficiency; 4. Children with autoimmune or rheumatic diseases; 5. Children with chronic diseases in active or progressive phases; 6. Children with confirmed malignancies; 7. Children who have undergone surgery within 3 days; 8. Children with fever within 3 days after vaccination; 9. Children who have used antipyretic medication within 6 hours; 10. Children who have used non-steroidal anti-inflammatory drugs (NSAIDs) within 6 hours; 11. Children with known allergies to the study drug; 12. Children deemed unsuitable by the investigator;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The temperature change difference 30 minutes after drug administration.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The ratio of patients whose body temperature returned to normal (axillary temperature =37.5°C) within 1 hour and 2 hours after drug administration.;Safety;The time from drug administration until the body temperature drops to =37.5°C (axillary temperature);The temperature change difference 1 hour and 2 hours after drug administration.; | — |
Countries
China
Contacts
Public ContactZeng Mei
children's hospital of fudan university
Outcome results
None listed