Hyperalgesia and postoperative analgesia
Conditions
Interventions
Group P:1~1.5h before induction of anesthesia: no preoperative medication
Postoperative wakefulness (after being able to drink water): patient (NRS score =3) took 2 oral dexibuprofen capsules
Group D:1~1.5h before induction of anesthesia: 2 capsules of dexibuprofen given by the study coordinator, 5~10ml of warm water.
Postoperative wakefulness: same as group P.
Group C:Before induction of anesthesia 1-1.5h: 2 capsules of celecoxib were given by the study coordinator with 5-10ml of warm water.
Postoperative wakefulness: 1 capsule of celecoxib was given orally
Sponsors
Sanbo Brain Hospital of Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists ASAI to Class II patients after elective neurosurgical craniotomy; 2. Patients aged 18 to 60 years old (including 18 years old as well as 60 years old) of both sexes; 3. Subjects voluntarily agreed to participate in this study and signed a written informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe cardiac, hepatic, or renal dysfunction or other serious systemic diseases; 2. Patients with suspected or a history of alcohol or drug abuse; 3. Post-neurosurgical patients requiring prolonged sedation or mechanical ventilation; 4. Patients with a known hypersensitivity to aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs), particularly those who have experienced asthma, neurovascular edema, or shock following exposure; 5. Patients currently participating in another clinical trial involving investigational drugs prior to enrollment; 6. Patients with hearing, visual, or speech impairments that may interfere with the ability to complete study assessments; 7. Patients with a history of active peptic ulcer disease or gastrointestinal bleeding or perforation of any known cause; 8. Patients with coagulation disorders or those receiving anticoagulant therapy; 9. Patients undergoing intraoperative neurophysiological monitoring, such as those with posterior cranial fossa tumors; 10. Patients with swallowing disorders or dysphagia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean arterial pressure during anterior and posterior upper head frame, skinning, sawing the skull, clipping the dura mater, removing the middle of the tumor, hemostasis, suturing the dura mater, repositioning the bone flap, suturing the fascia, and suturing the skin;Heart rate during anterior and posterior upper head frame, skinning, sawing the skull, cutting the dura, removing the tumor center, hemostasis, suturing the dura, bone flap repositioning, suturing the fascia, and suturing the skin;End-expiratory sevoflurane concentration during anterior and posterior upper head frame, skinning, sawing the skull, cutting the dura, removing the tumor midway, hemostasis, suturing the dura, repositioning the bone flap, suturing the fascia, and suturing the skin;Minimum effective concentration of alveoli during anterior and posterior upper head frame, skinning, sawing of the skull, cutting of the dura mater, removal of the tumor center, hemostasis, suturing of the dura mater, repositioning of the bone flap, suturing of the fascia, and suturing of the skin;NRS scores in the quiet state and in the coughing state were assessed at 8-10 am and 16-18 pm on postoperative days 1, 2, and 3 in all three groups.;Recovery time of spontaneous respiration, recovery time of orientation, and extubation time of patients in 3 groups; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate, blood pressure, respiration, and body temperature before and 1 minute, 3 minutes, and 5 minutes after intubation for induction of general anesthesia;Patient anesthesia time, surgery time;Incidence of hypertension, arrhythmia, agitation and chills during recovery from anesthesia;Occurrence and incidence of adverse reactions in patients after drug administration; | — |
Countries
China
Contacts
Public ContactWang Baoguo
Sanbo Brain Hospital of Capital Medical University
Outcome results
None listed