Children Undergoing Tonsillectomy
Conditions
Interventions
Tegileridine 0.005 mg/kg group:Intravenous injection of Tegileridine 0.005 mg/kg + normal saline up to 5 ml
Tegileridine 0.01 mg/kg group:Intravenous injection of Tegileridine 0.01 mg/kg + normal saline up to 5 ml
Tegileridine 0.015 mg/kg group:Intravenous injection of Tegileridine 0.015 mg/kg + normal saline up to 5 ml
placebo group:Inject 5 ml of normal saline intravenously.
Sponsors
The Second Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
5 Years to 12 Years
Inclusion criteria
Inclusion criteria: (1) Children and adolescents aged 5-12 years undergoing elective pediatric tonsillectomy +/- adenoidectomy; (2) ASA I-II; (3) families willing to participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Individuals with autism and developmental delays, or cognitive impairments; (2) Those with a history of severe heart, brain, lung, liver, or kidney diseases; (3) Preoperative electrolyte imbalance, preoperative analgesic treatment, or a history of allergies to surgical procedures or study drugs; (4) History of neuromuscular system diseases or mental illnesses; (5) With a history of respiratory or cardiac diseases; (6) Presence of bleeding risk; (7) Family members unwilling to cooperate or refuse to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient visual analogue score (VAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| The number and frequency of patients receiving fentanyl rescue analgesia during the recovery period;Vital signs at each observation time - point: heart rate, non - invasive blood pressure, respiratory rate, pulse oxygen saturation;Extubation time;Duration of stay in PACU;Cumulative opioid consumption within 0 - 24 hours after administration of the investigational drug;PAED;Document various adverse reactions occurring in pediatric patients;Pediatric Patient and Family Satisfaction Score; | — |
Countries
China
Contacts
Public ContactYingbin Wang
The Second Hospital of Lanzhou University
Outcome results
None listed