Gastrointestinal tumor
Conditions
Interventions
Experimental group:Thirty minutes before the end of the operation, Teligidine at a dose of 8 µg/kg was intravenously injected. At the end of the operation, an analgesic pump was connected: Teligidine
Control group:Thirty minutes before the end of the operation, sufentanil at a dose of 0.2 µg/kg was intravenously injected. After the operation, an analgesic pump was connected: sufentanil at a dose o
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Age >=65 years old, <=85 years old, ASA grade II - III; 2. Laparoscopic gastric cancer surgery and/or laparoscopic colorectal cancer surgery are planned to be performed under general anesthesia; 3. The informed consent form can be signed; 4. Have the ability to read and write.
Exclusion criteria
Exclusion criteria: 1. Patients with severe respiratory depression, such as those with oxygen saturation below 90%, and those with acute or severe bronchial asthma; 2. Emergency surgery patients; 3. Those with severe dementia, language disorders, or severe hearing or vision impairment who are unable to complete the questionnaire survey; 4. Those who have severe heart, lung, liver or kidney dysfunction before the operation; 5. Those with a history of chronic pain and those who have been taking analgesic and sedative drugs for a long time; 6. Those with mental illness and cognitive dysfunction; 7. Known or suspected gastrointestinal obstruction, including patients with paralytic intestinal obstruction; 8. Patients who are allergic to opioid drugs or any of the components of this product.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The area under the cumulative curve (AUC) of the NRS score for pain at rest within 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain scores at each time point;Number of PCA compressions;Anal exhaust time;Time of first eating;Diamine oxidase (DAO), D-lactic acid (D-LAC), Bacterial endotoxin (BE);The incidence of postoperative adverse reactions or complications (postoperative delirium, nausea, vomiting, pneumonia, transfer to ICU, hypoxia, intestinal obstruction) in patients;Postoperative rehabilitation quality;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactTianxiao Liu
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed