Throat diseases
Conditions
Interventions
Test group :Induction of general anesthesia with Alfentanyl 25 µ g/kg, maintaining pump infusion of Alfentanyl 0.5-2 µ g · kg-1 · min-1 (concentration of 100 µ g/ml)
Control group:Induction of general anesthesia with Sufentanyl 0.3 µ g/kg.
Sponsors
Ziyang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Gender is not limited. Age: 18 to 64 years old. 2. American Society of Anesthesiologists (ASA) physical status classification I to II. 3. Body Mass Index (BMI): 18 kg/m² to 30 kg/m².
Exclusion criteria
Exclusion criteria: 1. Refusal to participate in the study 2. Pregnancy and lactation 3. Allergy to opioids or propofol 4. ASA grade III or above 5. NYHA cardiac function classification grade III to IV 6. Uncontrolled severe hypertension or hypotension (systolic blood pressure = 160 mmHg, diastolic blood pressure = 100 mmHg, systolic blood pressure = 90 mmHg, diastolic blood pressure = 60 mmHg, meeting any one of these criteria is sufficient) 7. Coronary heart disease or severe arrhythmia 8. Severe liver or kidney disease 9. Severe neurological or mental system diseases 10. Long-term regular use of analgesics, psychotropic drugs (including opioids, sedatives, antidepressants, antiepileptic drugs), and a2-adrenergic receptor agonists within 3 months before the start of the screening period. 11. Communication barriers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maximum rate of change in systolic and diastolic pressure after endotracheal intubation and after placement of the supporting laryngoscope;The stability of RPP after endotracheal intubation and support laryngoscope placement (RPP is the product of heart rate and systolic blood pressure, i.e. SBP × HR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Wake-up time;Pull out time;Visual Analog Scale for Pharyngeal Pain;Coughing reaction;Intubation reaction; | — |
Countries
China
Contacts
Public ContactJiaman Li
Ziyang Central Hospital
Outcome results
None listed