None listed
Conditions
Interventions
Placebo control group:Routine anesthesia induction
Nicotine patch group:Nicotine patch 21mg/42mg - 21mg patch per 20 sticks, 40 cigarettes per day >= use 42mg dosage form patch
Sponsors
Henan Provincial People's Hospita,medical
Eligibility
Sex/Gender
Male
Age
25 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Male, aged 25-70 years old, BMI between 18-28; 2.thoracoscopic lobectomy under general anesthesia; 3.American Society of Anesthesiologists (ASA) grade I-III; 4.regular smoking for more than 2 years, smoking more than 10 cigarettes per day in the past 6 months, and not successfully quitting smoking within 1 month, Fagerstrom score >=2 [34]; 5.No serious respiratory diseases, no serious cardiovascular and cerebrovascular diseases (hypertension is treated with SBP<=160mmHg, DBP<=90mmHg); 6. Obtain informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who have a history of alcoholism, long-term use of sedatives or analgesics; 2. Patients with psychiatric or neurological diseases (such as Parkinson's, depression, schizophrenia) and severe audio-visual dysfunction before surgery; 3.systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg; 4. bleeding > 1000 ml or blood transfusion during surgery (participants bleeding more than 1000 ml or blood transfusion may be in a state of shock and require ventilation support after surgery, which may affect the outcome of postoperative pain assessment); 5.Patients who refuse to be treated with analgesic pumps.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative analgesic pump dosage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical pain threshold;VAS score;Sleep quality score;Postoperative adverse events;Total length of hospital stay; | — |
Countries
China
Contacts
Public ContactJiaqiang Zhang
Henan Provincial People's Hospita,medical
Outcome results
None listed