Mild cognitive impairment
Conditions
Interventions
MCI Test Group:After waking up naturally in the morning every day, the subjects in the experimental group were treated with Re-Timer LED light-emitting glasses for visual light stimulation for 1 hour
MCI Control Group:The control group was given comfort therapy with glasses with a similar shape and unable to shine for 4 weeks.
Healthy Control Group:None
Sponsors
The Fourth People's Hospital of Chengdu; The Clinical Hospital of Chengdu Brain Science Institute
Eligibility
Sex/Gender
All
Age
45 Years to 90 Years
Inclusion criteria
Inclusion criteria: This project plans to collect 100 MCI patients in the memory clinic and nearby communities, and divide them into the experimental group and the control group, with 50 cases in each group matched with age, gender, and education level. All the patients in the group meet the jak/bondi diagnostic criteria, that is, in the six indicators of the three cognitive domains (memory, executive function and language), memory, executive function and language, they are diagnosed as MCI if they meet the following conditions: 1. The scores of two tests in the same cognitive domain were impaired (>1.0sd); 2. Or 1 test score was impaired in all three cognitive domains (>1.0sd); 3. Not meeting the diagnostic criteria for dementia established by DSM-V (Diagnostic and Statistical Manual of Mental Disorders, 5th edition); 4. Hearing is allowed to complete the neuropsychological assessment; 5. No history of visual impairment-related diseases; 6. Did not take drugs that affect cognition, emotion and sleep rhythm, such as psychiatric drugs and mental retardation drugs; 7. There were no contraindications related to magnetic resonance imaging, such as metal teeth, cardiac pacemakers, and metal implants.
Exclusion criteria
Exclusion criteria: 1. History of cerebrovascular disease, brain trauma, tumours, or severe depression; 2. Other neurological diseases (such as Parkinson's disease, epilepsy, etc.) and systemic diseases (such as thyroid dysfunction, severe anaemia, syphilis, HIV infection, etc.) that may cause cognitive impairment; 3. History of psychiatric disorders or congenital mental retardation; 4. Use of psychotropic, nootropic, or other medications affecting cognition, mood, and sleep rhythms within one month before the start of the trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Efficacy Indicators (Cognition, Emotion, Sleep);Thalamocortical Structural and Functional Network Change Characteristics; | — |
Countries
China
Contacts
Public ContactZiqi Wang
The Fourth People's Hospital of Chengdu; The Clinical Hospital of Chengdu Brain Science Institute
Outcome results
None listed