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Can salidroside improve the pregnancy outcome of IVF patients of high reproductive age with poor prognosis? A randomized controlled clinical study

Can salidroside improve the pregnancy outcome of IVF patients of high reproductive age with poor prognosis? A randomized controlled clinical study

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2500104061
Enrollment
Unknown
Registered
2025-06-10
Start date
2025-06-10
Completion date
Unknown
Last updated
2025-06-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

female infertility

Interventions

Salidroside group :he salidroside group began to take oral Salidroside capsules (Tibet Gaoyuan 'an Biotechnology Development Co., LTD.) on the day of entering the COS cycle, once a day, 2 capsules eac
blank control group:The blank control group did not take Rhodiola rosea capsules orally after entering the COS cycle.

Sponsors

The Second Hospital of Shandong University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
35 Years to 40 Years

Inclusion criteria

Inclusion criteria: 1. Age >= 35 years and < 40 years 2. Those scheduled for the first or second cycle of IVF, ICSI, or donor sperm IVF 3. Meeting the 2016 Poseidon poor prognosis diagnostic criteria: 1-9 retrieved oocytes in the previous cycle with a conventional ovulation induction protocol, or bilateral ovarian AFC < 5 or AMH < 1.2 ng/ml (determined within the last six months)

Exclusion criteria

Exclusion criteria: 1. Patients with coagulation disorders 2. Patients with a history of abnormal uterine bleeding 3. Patients with hydrosalpinx confirmed by B-ultrasound and HSG 4. Patients with uterine malformations (unicornuate uterus, septate uterus) or a history of intrauterine adhesions 5. Patients with >=3 spontaneous abortions in the past 6. Patients with contraindications to assisted reproductive technology or pregnancy 7. Patients who have taken or are currently taking drugs containing salidroside 8. Patients whose controlled ovarian stimulation protocol is PPOS protocol, luteal phase ovulation induction protocol, or continuous stimulation protocol

Design outcomes

Primary

MeasureTime frame
Continuous pregnancy rate;

Countries

China

Contacts

Public ContactCuiLinlin

The Second Hospital of Shandong University

fdclear3@126.com+86 176 6008 9116

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026